Treat Excessive Sweating in New York
Hyperhidrosis Treatment on Fifth Avenue, NYC
Hyperhidrosis—also called excessive sweating—can impact daily life, wardrobe choices, and confidence. At Dr. Dennis Gross Dermatology, we take a patient-first approach to diagnosing and treating hyperhidrosis at our New York practice so you can get back to work, workouts, and social plans without constant concern.
READY TO SCHEDULE YOUR HYPERHIDROSIS CONSULTATION IN NEW YORK CITY WITH DR. DENNIS GROSS DERMATOLOGY?
Call (212) 725-4555 or book an appointment online with our team—we’ll create a personalized plan to help you feel drier, more comfortable, and confident. We serve Manhattan, Queens, Brooklyn, Staten Island, Bronx, and the surrounding communities, including New Jersey and Connecticut.
What is Hyperhidrosis?
Hyperhidrosis is a condition characterized by sweating that exceeds the body’s temperature-regulation needs. It commonly affects the underarms, palms, soles, and face. Primary (idiopathic) hyperhidrosis often begins in adolescence and is not caused by another medical issue, while secondary hyperhidrosis can be related to medications or underlying conditions. We carefully review your history and pattern of sweating to guide the right excessive sweating treatment.
Why Excessive Sweating Happens
In primary hyperhidrosis, overactive cholinergic nerve signals trigger sweat glands to produce more sweat than necessary. Triggers may include heat, stress, exercise, or specific activities like typing or public speaking. Hyperhidrosis is a cosmetic treatment at Dennis Gross Dermatology. We evaluate your symptoms and, treat each patient appropriately.
BOTOX® for Hyperhidrosis Treatment
How Botulinum Toxin for Hyperhidrosis Works
We treat hyperhidrosis with BOTOX® (onabotulinumtoxinA). Botulinum toxin temporarily blocks the nerve signals that tell sweat glands to activate. For underarm hyperhidrosis, BOTOX® is FDA approved for adults who have not had satisfactory results with topical antiperspirants. We may also treat palms, soles, and other areas as medically appropriate (off-label) after an in-person evaluation.
Your Treatment Experience
Most sessions take about 20–30 minutes but can take longer depending on areas treated. We review the treatment area, cleanse the skin, and use a fine needle to place tiny amounts of BOTOX® just under the skin. To support comfort, we can use topical numbing. You can return to normal activities right away, avoiding vigorous exercise and hot environments for the first 24 hours.
Results, Longevity, and Maintenance
Many patients begin noticing reduced sweating within 2–7 days, with optimal dryness around 2 weeks. Underarm results typically last 4–6 months, and sometimes longer; palms and soles may require touch-ups closer to every 3–5 months. Maintenance timing varies by individual physiology and lifestyle, and we tailor a plan to your goals.
Dr. Dennis Gross
Decades of Distinction
Behind every treatment is decades of research, training, and expertise. We are dedicated to helping our patients look and feel their best.

25+ years as a board-certified dermatologist and dermatologic surgeon, founder of his 5th Avenue Manhattan practice. A New York Magazine Best Doctor and a trusted voice on national TV, from The Today Show to CNN. He’s also the author of Your Future Face: The Customized Plan to Look Younger at Any Age. 25+ years as a board-certified dermatologist and dermatologic surgeon.
World-Renowned Dermatologist
Founded his award-winning skincare brand in 2000, now carried by Sephora, Nordstrom, and MECCA Beauty. He continues to serve as the brand’s Chief Science Officer.
Founder of Dr. Dennis Gross Skincare™
Before opening his practice, Dr. Gross conducted extensive melanoma research at Memorial Sloan Kettering Cancer Center, studying how the immune system recognizes cancer cells. His findings were published in peer-reviewed journals including the Journal of Experimental Medicine and the Journal of Medical Microbiology.
Skin Cancer Research
A native New Yorker, Dr. Gross has spent his career and personal life rooted in the city he serves. He sits on the Board of Animal Care Centers of NY, championing animal welfare initiatives across the five boroughs, and shares a busy family life in Manhattan with his wife and business partner, Carrie, and their four children.
Beyond the Practice
Our Experts
Your Trusted Experts in Professional Dermatology
Lara Battema, LE, MPH
Lia Trojansky, PA-C
Hilary Reich M.D.
BOTOX® for Hyperhidrosis Treatment
How Botulinum Toxin for Hyperhidrosis Works
Your Treatment Experience
Results, Longevity, and Maintenance
Candidacy, Safety, and Recovery
You may be a good candidate if excessive sweating interferes with daily life, you’ve tried medical-strength antiperspirants without adequate relief, and you are not pregnant or nursing. We will review your medical history, medications, and prior treatments to ensure BOTOX® is an appropriate excessive sweating treatment for you.
BOTOX® for hyperhidrosis is well studied. Common temporary effects can include mild tenderness, swelling, or bruising at injection sites. Palmar treatment can occasionally cause temporary hand weakness. Serious side effects are uncommon but possible; we discuss risks and provide aftercare instructions so you know exactly how to care for the area.
FAQ
Let’s Talk About Your Skin’s Needs
We’re here to make your skincare journey simple, stress-free, and tailored just for you.
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Most patients notice improvement within the first week, with peak dryness around 14 days. If needed, we schedule a follow-up to assess your response and plan maintenance.
At Dennis Gross Dermatology, hyperhidrosis is a cosmetic treatment and we do not submit to insurance.
Underarm hyperhidrosis treatment with BOTOX® is FDA approved for adults who fail topical therapy. Treating the palms, soles, forehead, and other areas can be considered off-label based on your exam and goals.
We commonly see patients who have tried prescription antiperspirants or glycopyrronium wipes, oral anticholinergics, iontophoresis, or energy-based devices. While results vary, BOTOX® offers targeted, non-surgical control with predictable, time-limited effects and no downtime for most patients.
Haven’t got an answer?
Book An Appointment Online.
Find Your Perfect Skincare Plan
Take the next step toward drier days. Schedule your hyperhidrosis treatment at New York’s Dr. Dennis Gross Dermatology on Fifth Avenue. Call (212) 725-4555 or book an appointment online with our team.
Comprehensive Dermatology Care for NYC
Other Skin Conditions and Treatments We Offer
Beyond hyperhidrosis, Dr. Dennis Gross Dermatology evaluates and treats a wide range of concerns, including acne, skin cancer (screenings, biopsies, and treatment), psoriasis, rosacea, eczema, melasma, and various skin growths such as skin tags, warts, moles, cysts, and seborrheic keratoses. Depending on your diagnosis and goals, we may recommend evidence-based therapies like prescription topicals, oral medications, in-office procedures (for example, chemical peels, laser and LED, cryotherapy), and preventive skincare guidance. If you are managing more than one concern, we can coordinate a stepwise plan that fits your schedule and comfort.



